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A protein at the heart of heart diseaseMizzou researchers discover the structure of a protein that could lead to more targeted heart disease treatments.

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The molecular structure of LDL has finally been elucidated - Nature Reviews CardiologyTwo studies published in Nature report the structure of apolipoprotein B100 on LDL using high-resolution, artificial intelligence-assisted cryo-electron microscopy and uncover its precise molecular interfaces with the LDL receptor. Dimers of LDL particles connected by a pair of receptors are also visualized for the first time. These studies provide key structural insights into the molecular defects linked to familial hypercholesterolaemia and open exciting avenues for translational research and drug development.

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The structure of bad cholesterol comes into focusHigh-resolution structures of low-density lipoprotein.

Cholesterol-wrapping lipoprotein gets a closer lookStructures of ApoB100 show LDL receptor contact points

PDB101: Molecule of the Month: Apolipoprotein B-100 and LDL ReceptorInsights into how LDL is removed from the bloodstream

A protein at the heart of heart disease

FightingLDL_ST.mp4

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